

that was called back due to Harrison stepping out of bounds before catching the pass. After another Indiana punt, Ohio State would have their most successful drive of the day, with McCord finding tight end Cade Stover for a 49-yard completion as well as a would-be touchdown pass to star wideout Marvin Harrison Jr. Ohio State was then able to drive deep into Indiana territory, but a missed read on a quarterback run by McCord caused the Buckeye offense to stall in the red zone, resulting in a 22-yard field goal by Fielding to extend the Buckeyes' lead to 13-3. The teams traded punts to open the second half. The half would come to an end with Ohio State taking advantage of a fourth-down stop by safety Josh Proctor and a taunting penalty against Indiana to allow kicker Jayden Fielding to kick a 40-yard field goal, giving Ohio State a 10–3 lead at the break. Brown would see his first snaps on Ohio State's ensuing possession, but would be sacked on third down by defensive lineman Andre Carter, forcing another punt. Indiana would drive down the field after this interception, and would score their first points on a 42-yard field goal by kicker Chris Freeman that bounced off the right upright and through.

Ohio State would go on a long drive to start the second quarter, driving down to the Indiana 29, where on 4th-and-2 McCord's pass would be intercepted by defensive back Philip Dunnam after his primary target, running back Chip Trayanum, was knocked over by a Hoosier defender. The two teams would then trade punts until the end of the first quarter, with Ohio State's defense able to stifle Indiana's unexpected triple option offense. McCord and the Buckeyes would then march down the field, punctuated by a 7-yard touchdown from senior running back Miyan Williams. The game began with Indiana going three-and-out, with a third-down stop by linebacker Steele Chambers forcing the Hoosiers to punt. In the week leading up to the game, coach Ryan Day said that junior Kyle McCord would start for the Buckeyes in their opener, with redshirt freshman Devin Brown also expected to see playing time. Ohio State entered the game having won 27 straight meetings against the Hoosiers. As part of the Big Ten's new media rights deal, an Ohio State game would be broadcast on CBS for the first time since 2014. Ohio State opened its season with a 23–3 victory on September 2 against the Indiana Hoosiers in front of a near-capacity crowd of 50,050 at Memorial Stadium.

6:42 OSU - Jayden Fielding 22-yard field goal - Ohio State 13-3, Drive: 11 plays, 76 yards, 5:24.

0:03 OSU - Jayden Fielding 40-yard field goal - Ohio State 10-3, Drive: 6 plays, 35 yards, 0:35.6:15 IND - Chris Freeman 42-yard field goal - Ohio State 7-3, Drive: 8 plays, 43 yards, 4:03.7:16 OSU - Miyan Williams 7-yard run (Jayden Fielding kick) - Ohio State 7-0, Drive: 11 plays, 80 yards, 5:34.
